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Anti-PBRM1 Antibody Picoband® Biotin Conjugated

Product Specifications

Background

This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.

Synonyms

PBRM1; BAF180; PB1; Protein polybromo-1; hPB1; BRG1-associated factor 180; BAF180; Polybromo-1D

Gene Name

PBRM1

Gene ID

55193

UniProt

Q86U86

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human PBRM1 recombinant protein (Position: D45-R1647) .

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Benusiglio, P. R., Couve, S., Gilbert-Dussardier, B., Deveaux, S., Le Jeune, H., Da Costa, M., Fromont, G., Memeteau, F., Yacoub, M., Coupier, I., Leroux, D., Mejean, A., and 8 others. A germline mutation in PBRM1 predisposes to renal cell carcinoma. J. Med. Genet. 52: 426-430, 2015. 2. Lemon, B., Inouye, C., King, D. S., Tjian, R. Selectivity of chromatin-remodeling cofactors for ligand-activated transcription. Nature 414: 924-928, 2001. 3. Miao, D., Margolis, C. A., Gao, W., Voss, M. H., Li, W., Martini, D. J., Norton, C., Bosse, D., Wankowicz, S. M., Cullen, D., Horak, C., Wind-Rotolo, M., and 14 others. Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. Science 359: 801-806, 2018.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

193 kDa

Gene Name Synonym

Polybromo 1

Protein Name

Protein polybromo-1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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