Anti-PBRM1 Antibody Picoband®

This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.

1. Benusiglio, P. R., Couve, S., Gilbert-Dussardier, B., Deveaux, S., Le Jeune, H., Da Costa, M., Fromont, G., Memeteau, F., Yacoub, M., Coupier, I., Leroux, D., Mejean, A., and 8 others. A germline mutation in PBRM1 predisposes to renal cell carcinoma. J. Med. Genet. 52: 426-430, 2015. 2. Lemon, B., Inouye, C., King, D. S., Tjian, R. Selectivity of chromatin-remodeling cofactors for ligand-activated transcription. Nature 414: 924-928, 2001. 3. Miao, D., Margolis, C. A., Gao, W., Voss, M. H., Li, W., Martini, D. J., Norton, C., Bosse, D., Wankowicz, S. M., Cullen, D., Horak, C., Wind-Rotolo, M., and 14 others. Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma. Science 359: 801-806, 2018.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.