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Anti-NUP93 Antibody Picoband® APC Conjugated

Product Specifications

Background

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene encodes a nucleoporin protein that localizes both to the basket of the pore and to the nuclear entry of the central gated channel of the pore. The encoded protein is a target of caspase cysteine proteases that play a central role in programmed cell death by apoptosis. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms

NUP93; KIAA0095; Nuclear pore complex protein Nup93; 93 kDa nucleoporin; Nucleoporin Nup93

Gene Name

NUP93

Gene ID

9688

UniProt

Q8N1F7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human NUP93 recombinant protein (Position: M1-Q677) . Human NUP93 shares 97.8% amino acid (aa) sequence identity with both mouse and rat NUP93.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Braun, D. A., Sadowski, C. E., Kohl, S., Lovric, S., Astrinidis, S. A., Pabst, W. L., Gee, H. Y., Ashraf, S., Lawson, J. A., Shril, S., Airik, , M., Tan, W., and 15 others. Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome. Nature Genet. 48: 457-465, 2016. 2. Grandi, P., Dang, T., Pane, N., Shevchenko, A., Mann, M., Forbes, D., Hurt, E. Nup93, a vertebrate homologue of yeast Nic96p, forms a complex with a novel 205-kDa protein and is required for correct nuclear pore assembly. Molec. Biol. Cell 8: 2017-2038, 1997. 3. Hartz, P. A. Personal Communication. Baltimore, Md. 9/15/2011.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

93 kDa

Applications Notes

6

Gene Name Synonym

Nucleoporin 93

Protein Name

Nuclear pore complex protein Nup93

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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