Anti-NAA60 Antibody Picoband®

This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcript variants. The upstream promoter is located in a differentially methylated region (DMR) and undergoes imprinting; transcript variants originating from this position are expressed from the maternal allele.

NAA60; HAT4; NAT15; UNQ2771/PRO7155; N-alpha-acetyltransferase 60; hNaa60; EC 2.3.1.259; Histone acetyltransferase type B protein 4; HAT4; EC 2.3.1.48; N-acetyltransferase 15; N-alpha-acetyltransferase F; NatF

E.coli-derived human NAA60 recombinant protein (Position: M1-M242) . Human NAA60 shares 97.1% and 97.5% amino acid (aa) sequence identity with mouse and rat NAA60, respectively.

1. Chelban, V., Aksnes, H., Maroofian, R., LaMonica, L. C., Seabra, L., Siggervag, A., Devic, P., Shamseldin, H. E., Vandrovcova, J., Murphy, D., Richard, A. C., Quenez, O., and 48 others. Biallelic NAA60 variants with impaired N-terminal acetylation capacity cause autosomal recessive primary familial brain calcifications. Nature Commun. 15: 2269, 2024. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 9/22/2011. 3. Nakabayashi, K., Trujillo, A. M., Tayama, C., Camprubi, C., Yoshida, W., Lapunzina, P., Sanchez, A., Soejima, H., Aburatani, H., Nagae, G., Ogata, T., Hata, K., Monk, D. Methylation screening of reciprocal genome-wide UDPs identifies novel human-specific imprinted genes. Hum. Molec. Genet. 20: 3188-3197, 2011.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.