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Anti-PCYT2 Antibody Picoband® APC Conjugated

Product Specifications

Background

This gene encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Alternative splicing results in multiple transcript variants.

Synonyms

PCYT2; Ethanolamine-phosphate cytidylyltransferase; EC 2.7.7.14; CTP:phosphoethanolamine cytidylyltransferase; Phosphorylethanolamine transferase

Gene Name

PCYT2

Gene ID

5833

UniProt

Q99447

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human PCYT2 recombinant protein (Position: D32-F389) . Human PCYT2 shares 89.5% and 94.4% amino acid (aa) sequence identity with mouse and rat PCYT2, respectively.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Christen, M., Oevermann, A., Rupp, S., Vaz, F. M., Wever, E. J. M., Braus, B. K., Jagannathan, V., Kehl, A., Hytonen, M. K., Lohi, H., Leeb, T. PCYT2 deficiency in Saarlooswolfdogs with progressive retinal, central, and peripheral neurodegeneration. Molec. Genet. Metab. 141: 108149, 2024. 2. Fullerton, M. D., Hakimuddin, F., Bakovic, M. Developmental and metabolic effects of disruption of the mouse CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2) . Molec. Cell Biol. 27: 3327-3336, 2007. 3. Kaiyrzhanov, R., Wortmann, S., Reid, T., Dehghani, M., Vahidi Mehrjardi, M. Y., Alhaddad, B., Wagner, M., Deschauer, M., Cordts, I., Fernandez-Murray, J. P., Treffer, V., Metanat, Z., Pittman, A., Houlden, H., Meitinger, T., Carroll, C., McMaster, C. R., Maroofian, R. Defective phosphatidylethanolamine biosynthesis leads to a broad ataxia-spasticity spectrum. Brain 144: e30, 2021. Note: Erratum: Brain 144: e52, 2021.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

44 kDa

Applications Notes

6

Gene Name Synonym

Phosphate cytidylyltransferase 2, ethanolamine

Protein Name

Ethanolamine-phosphate cytidylyltransferase

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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