Anti-PARG Antibody Picoband® APC Conjugated

Poly (ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly (ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products. Several transcript variants encoding different isoforms have been found for this gene.

E.coli-derived human PARG recombinant protein (Position: D27-R854) . Human PARG shares 86.5% and 84.7% amino acid (aa) sequence identity with mouse and rat PARG, respectively.

1. Ame, J.-C., Apiou, F., Jacobson, E. L., Jacobson, M. K. Assignment of the poly (ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization. Cytogenet. Cell Genet. 85: 269-270, 1999. 2. Andrabi, S. A., Kim, N. S., Yu, S.-W., Wang, H., Koh, D. W., Sasaki, M., Klaus, J. A., Otsuka, T., Zhang, Z., Koehler, R. C., Hurn, P. D., Poirier, G. G., Dawson, V. L., Dawson, T. M. Poly (ADP-ribose) (PAR) polymer is a death signal. Proc. Nat. Acad. Sci. 103: 18308-18313, 2006. 3. Hanai, S., Kanai, M., Ohashi, S., Okamoto, K., Yamada, M., Takahashi, H., Miwa, M. Loss of poly (ADP-ribose) glycohydrolase causes progressive neurodegeneration in Drosophila melanogaster. Proc. Nat. Acad. Sci. 101: 82-86, 2004.