Anti-PAM Antibody Picoband® Biotin Conjugated

This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.

PAM; Peptidyl-glycine alpha-amidating monooxygenase; PAM [Includes: Peptidylglycine alpha-hydroxylating monooxygenase; PHM; EC 1.14.17.3; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase; EC 4.3.2.5; Peptidylamidoglycolate lyase; PAL]

1. Eipper, B. A., Green, C. B.-R., Campbell, T. A., Stoffers, D. A., Keutmann, H. T., Mains, R. E., Ouafik, L.'H. Alternative splicing and endoproteolytic processing generate tissue-specific forms of pituitary peptidylglycine alpha-amidating monooxygenase (PAM) . J. Biol. Chem. 267: 4008-4015, 1992. 2. Glauder, J., Ragg, H., Rauch, J., Engels, J. W. Human peptidylglycine alpha-amidating monooxygenase: cDNA, cloning and functional expression of a truncated form in COS cells. Biochem. Biophys. Res. Commun. 169: 551-558, 1990. 3. Gross, M. B. Personal Communication. Baltimore, Md. 5/17/2021.