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Anti-GHRHR Antibody Picoband® HRP Conjugated

Product Specifications

Background

This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature.

Synonyms

GHRHR; Growth hormone-releasing hormone receptor; GHRH receptor; Growth hormone-releasing factor receptor; GRF receptor; GRFR

Gene Name

GHRHR

Gene ID

2692

UniProt

Q02643

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human GHRHR recombinant protein (Position: H23-K407) . Human GHRHR shares 84.8% and 85.6% amino acid (aa) sequence identity with mouse and rat GHRHR, respectively.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Aguiar-Oliveira, M. H., Gill, M. S., de A. Barretto, E. S., Alcantara, M. R. S., Miraki-Moud, F., Menezes, C. A., Souza, A. H. O., Martinelli, C. E., Pereira, F. A., Salvatori, R., Levine, M. A., Shalet, S. M., Camacho-Hubner, C., Clayton, P. E. Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life. J. Clin. Endocr. Metab. 84: 4118-4126, 1999. 2. DeAlmeida, V. I., Mayo, K. E. Identification and binding domains of the growth hormone-releasing hormone receptor by analysis of mutant and chimeric receptor proteins. Molec. Endocr. 12: 750-765, 1998. 3. Gaylinn, B. D., Harrison, J. K., Zysk, J. R., Lyons, C. E., Lynch, K. R., Thorner, M. O. Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone. Molec. Endocr. 7: 77-84, 1993.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

47 kDa

Gene Name Synonym

Growth hormone releasing hormone receptor

Protein Name

Growth hormone-releasing hormone receptor

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4.

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