Anti-GHRHR Antibody Picoband® FITC Conjugated

This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature.

E.coli-derived human GHRHR recombinant protein (Position: H23-K407) . Human GHRHR shares 84.8% and 85.6% amino acid (aa) sequence identity with mouse and rat GHRHR, respectively.

1. Aguiar-Oliveira, M. H., Gill, M. S., de A. Barretto, E. S., Alcantara, M. R. S., Miraki-Moud, F., Menezes, C. A., Souza, A. H. O., Martinelli, C. E., Pereira, F. A., Salvatori, R., Levine, M. A., Shalet, S. M., Camacho-Hubner, C., Clayton, P. E. Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life. J. Clin. Endocr. Metab. 84: 4118-4126, 1999. 2. DeAlmeida, V. I., Mayo, K. E. Identification and binding domains of the growth hormone-releasing hormone receptor by analysis of mutant and chimeric receptor proteins. Molec. Endocr. 12: 750-765, 1998. 3. Gaylinn, B. D., Harrison, J. K., Zysk, J. R., Lyons, C. E., Lynch, K. R., Thorner, M. O. Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone. Molec. Endocr. 7: 77-84, 1993.