Anti-GHRHR Antibody Picoband® Biotin Conjugated
Product Specifications
Background
This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature.
Synonyms
GHRHR; Growth hormone-releasing hormone receptor; GHRH receptor; Growth hormone-releasing factor receptor; GRF receptor; GRFR
Gene Name
GHRHR
Gene ID
2692
UniProt
Q02643
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human GHRHR recombinant protein (Position: H23-K407) . Human GHRHR shares 84.8% and 85.6% amino acid (aa) sequence identity with mouse and rat GHRHR, respectively.
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Aguiar-Oliveira, M. H., Gill, M. S., de A. Barretto, E. S., Alcantara, M. R. S., Miraki-Moud, F., Menezes, C. A., Souza, A. H. O., Martinelli, C. E., Pereira, F. A., Salvatori, R., Levine, M. A., Shalet, S. M., Camacho-Hubner, C., Clayton, P. E. Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life. J. Clin. Endocr. Metab. 84: 4118-4126, 1999. 2. DeAlmeida, V. I., Mayo, K. E. Identification and binding domains of the growth hormone-releasing hormone receptor by analysis of mutant and chimeric receptor proteins. Molec. Endocr. 12: 750-765, 1998. 3. Gaylinn, B. D., Harrison, J. K., Zysk, J. R., Lyons, C. E., Lynch, K. R., Thorner, M. O. Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone. Molec. Endocr. 7: 77-84, 1993.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.
Calculated Molecular Weight
47 kDa
Gene Name Synonym
Growth hormone releasing hormone receptor
Protein Name
Growth hormone-releasing hormone receptor
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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