Anti-HERC4 Antibody Picoband® Biotin Conjugated

HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710) -like domain (RLD) . The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins.

HERC4; KIAA1593; Probable E3 ubiquitin-protein ligase HERC4; EC 2.3.2.26; HECT domain and RCC1-like domain-containing protein 4; HECT-type E3 ubiquitin transferase HERC4

E.coli-derived human HERC4 recombinant protein (Position: D18-I1057) . Human HERC4 shares 96.8% and 97% amino acid (aa) sequence identity with mouse and rat HERC4, respectively.

1. Hochrainer, K., Mayer, H., Baranyi, U., Binder, B. R., Lipp, J., Kroismayr, R. The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects. Genomics 85: 153-164, 2005. 2. Nagase, T., Kikuno, R., Nakayama, M., Hirosawa, M., Ohara, O. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 7: 273-281, 2000.