Anti-CHP1 Antibody Picoband®

This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity.

CHP1; CHP; Calcineurin B homologous protein 1; Calcineurin B-like protein; Calcium-binding protein CHP; Calcium-binding protein p22; EF-hand calcium-binding domain-containing protein p22

A synthetic peptide corresponding to a sequence at the N-terminus of human CHP1. Human CHP1 shares 100% amino acid (aa) sequence identity with both mouse and rat CHP1.

1. Lin, X., Barber, D. L. A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. Proc. Nat. Acad. Sci. 93: 12631-12636, 1996. 2. Lin, X., Sikkink, R. A., Rusnak, F., Barber, D. L. Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein. J. Biol. Chem. 274: 36125-36131, 1999. 3. Liu, Y., Zaun, H. C., Orlowski, J., Ackerman, S. L. CHP1-mediated NHE1 biosynthetic maturation is required for Purkinje cell axon homeostasis. J. Neurosci. 33: 12656-12669, 2013.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.