Anti-KCNA6 Antibody Picoband® Biotin Conjugated

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog (s) . This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class. The coding region of this gene is intronless, and the gene is clustered with genes KCNA1 and KCNA5 on chromosome 12.

A synthetic peptide corresponding to a sequence at the C-terminus of human KCNA6. Human KCNA6 shares 100% and 95.2% amino acid (aa) sequence identity with mouse and rat KCNA6, respectively.

1. Albrecht, B., Weber, K., Pongs, O. Characterization of a voltage-activated K-channel gene cluster on human chromosome 12p13. Receptors Channels 3: 213-220, 1995. 2. Chandy, K. G., Williams, C. B., Spencer, R. H., Aguilar, B. A., Ghanshani, S., Tempel, B. L., Gutman, G. A. A family of three mouse potassium channel genes with intronless coding regions. Science 247: 973-975, 1990. 3. Grupe, A., Schroter, K. H., Ruppersberg, J. P., Stocker, M., Drewes, T., Beckh, S., Pongs, O. Cloning and expression of a human voltage-gated potassium channel: a novel member of the RCK potassium channel family. EMBO J. 9: 1749-1756, 1990.