Anti-CD42a/GP9 Antibody Picoband® APC Conjugated

This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency.

A synthetic peptide corresponding to a sequence in the middle region of human CD42a/GP9. Human CD42a/GP9 shares 89.5% amino acid (aa) sequence identity with mouse CD42a/GP9.

1. Bernard, J., Caen, J., Maroteaux, P. La dystrophie thrombocytaire hemorragipare congenitale. Rev. Hemat. 12: 222-249, 1957. 2. Clemetson, J. M., Kyrle, P. A., Brenner, B., Clemetson, K. J. Variant Bernard-Soulier syndrome associated with a homozygous mutation in the leucine-rich domain of glycoprotein IX. Blood 84: 1124-1131, 1994. 3. Hickey, M. J., Deaven, L. L., Roth, G. J. Human platelet glycoprotein IX: characterization of cDNA and localization of the gene to chromosome 3. FEBS Lett. 274: 189-192, 1990.