Anti-GABBR2 Antibody Picoband® HRP Conjugated

The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.

GABBR2; GPR51; GPRC3B; Gamma-aminobutyric acid type B receptor subunit 2; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2; G-protein coupled receptor 51; HG20

E.coli-derived human GABBR2 recombinant protein (Position: D100-Q889) . Human GABBR2 shares 98.4% and 98.1% amino acid (aa) sequence identity with mouse and rat GABBR2, respectively.

1. Beuten, J., Ma, J. Z., Payne, T. J., Dupont, R. T., Crews, K. M., Somes, G., Williams, N. J., Elston, R. C., Li, M. D. Single- and multilocus allelic variants with the GABA (B) receptor subunit 2 (GABAB2) gene are significantly associated with nicotine dependence. Am. J. Hum. Genet. 76: 859-864, 2005. 2. Clark, J. A., Mezey, E., Lam, A. S., Bonner, T. I. Distribution of the GABA-B receptor subunit gb2 in rat CNS. Brain Res. 860: 41-52, 2000. 3. EuroEPINOMICS-RES Consortium, Epilepsy Phenome/Genome Project, Epi4K Consortium. De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies. Am. J. Hum. Genet. 95: 360-370, 2014. Note: Erratum: Am. J. Hum. Genet. 100: 179 only, 2017.