Anti-GCNT2 Antibody Picoband® APC Conjugated
Product Specifications
Background
This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.
Synonyms
GCNT2; GCNT5; II; NACGT1; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; N-acetylglucosaminyltransferase; EC 2.4.1.150; I-branching enzyme; IGNT
Gene Name
GCNT2
Gene ID
2651
UniProt
Q8N0V5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human GCNT2 recombinant protein (Position: E27-Q397) . Human GCNT2 shares 71.7% amino acid (aa) sequence identity with mouse GCNT2.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Bierhuizen, M. F. A., Mattei, M.-G., Fukuda, M. Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family. Genes Dev. 7: 468-478, 1993. 2. Lin-Chu, M., Broadberry, R. E., Okubo, Y., Tanaka, M. The i phenotype and congenital cataracts among Chinese in Taiwan (Letter) Transfusion 31: 676-677, 1991. 3. Marsh, W. L., DePalma, H. Association between the Ii blood group and congenital cataract. Transfusion 22: 337-338, 1982.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Product Datasheet
https://www.bosterbio.com/datasheet?sku=A07194-APC
Calculated Molecular Weight
46 kDa
Applications Notes
6
Gene Name Synonym
Glucosaminyl (N-acetyl) transferase 2 (I blood group)
Protein Name
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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