Anti-GCNT2 Antibody Picoband® HRP Conjugated

This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described.

GCNT2; GCNT5; II; NACGT1; N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase; N-acetylglucosaminyltransferase; EC 2.4.1.150; I-branching enzyme; IGNT

1. Bierhuizen, M. F. A., Mattei, M.-G., Fukuda, M. Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene family. Genes Dev. 7: 468-478, 1993. 2. Lin-Chu, M., Broadberry, R. E., Okubo, Y., Tanaka, M. The i phenotype and congenital cataracts among Chinese in Taiwan (Letter) Transfusion 31: 676-677, 1991. 3. Marsh, W. L., DePalma, H. Association between the Ii blood group and congenital cataract. Transfusion 22: 337-338, 1982.