Anti-NRCAM Antibody Picoband® Fluoro647 Conjugated

Enables protein binding activity involved in heterotypic cell-cell adhesion. Involved in cell-cell adhesion; nervous system development; and regulation of postsynapse organization. Acts upstream of or within several processes, including neuron development; neuronal action potential propagation; and regulation of neuron projection development. Located in axon; plasma membrane; and synapse. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study autism spectrum disorder. Orthologous to human NRCAM (neuronal cell adhesion molecule) .

E.coli-derived human NRCAM recombinant protein (Position: R207-Q1025) . Mouse NRCAM shares 91.7% and 97.1% amino acid (aa) sequence identity with human and rat NRCAM, respectively.

1. Custer, A. W., Kazarinova-Noyes, K., Sakurai, T., Xu, X., Simon, W., Grumet, M., Shrager, P. The role of the ankyrin-binding protein NrCAM in node of Ranvier formation. J. Neurosci. 23: 10032-10039, 2003. 2. Demyanenko, G. P., Mohan, V., Zhang, X., Brennaman, L. H., Dharbal, K. E. S., Tran, T. S., Manis, P. B., Maness, P. F. Neural cell adhesion molecule NrCAM regulates semaphorin 3F-induced dendritic spine remodeling. J. Neurosci. 34: 11274-11287, 2014. 3. Dry, K., Kenwrick, S., Rosenthal, A., Platzer, M. The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily. Gene 273: 115-122, 2001.