Anti-RYK Antibody Picoband® HRP Conjugated

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

1. Gough, N. M., Rakar, S., Hovens, C. M., Wilks, A. Localization of two mouse genes encoding the protein tyrosine kinase receptor-related protein RYK. Mammalian Genome 6: 255-256, 1995. 2. Halford, M. M., Armes, J., Buchert, M., Meskenaite, V., Grail, D., Hibbs, M. L., Wilks, A. F., Farlie, P. G., Newgreen, D. F., Hovens, C. M., Stacker, S. A. Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk. Nature Genet. 25: 414-418, 2000. 3. Hovens, C. M., Stacker, S. A., Andres, A.-C., Harpur, A. G., Wilks, A. F. RYK, a receptor tyrosine kinase-related molecule with unusual kinase domain motifs. Proc. Nat. Acad. Sci. 89: 11818-11822, 1992.