Anti-NKX2-2 Antibody APC Conjugated

The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.

A synthetic peptide corresponding to a sequence at the N-terminus of human NKX2-2. Human NKX2-2 shares 100% amino acid (aa) sequence identity with mouse NKX2-2.

1. Ding, Y.-Q., Marklund, U., Yuan, W., Yin, J., Wegman, L., Ericson, J., Deneris, E., Johnson, R. L., Chen, Z.-F. Lmx1b is essential for the development of serotonergic neurons. Nature Neurosci. 6: 933-938, 2003. 2. Furuta, H., Horikawa, Y., Iwasaki, N., Hara, M., Sussel, L., Le Beau, M. M., Davis, E. M., Ogata, M., Iwamoto, Y., German, M. S., Bell, G. I. Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese. Diabetes 47: 1356-1358, 1998. 3. Hartigan, D. J., Rubenstein, J. L. The cDNA sequence of murine Nkx-2.2. Gene 168: 271-272, 1996.