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Anti-NKX2-2 Antibody Fluoro488 Conjugated

Product Specifications

Background

The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.

Synonyms

NKX2-2; NKX2.2; NKX2B; Homeobox protein Nkx-2.2; Homeobox protein NK-2 homolog B

Gene Name

NKX2-2

Gene ID

4821

UniProt

O95096

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human NKX2-2. Human NKX2-2 shares 100% amino acid (aa) sequence identity with mouse NKX2-2.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Ding, Y.-Q., Marklund, U., Yuan, W., Yin, J., Wegman, L., Ericson, J., Deneris, E., Johnson, R. L., Chen, Z.-F. Lmx1b is essential for the development of serotonergic neurons. Nature Neurosci. 6: 933-938, 2003. 2. Furuta, H., Horikawa, Y., Iwasaki, N., Hara, M., Sussel, L., Le Beau, M. M., Davis, E. M., Ogata, M., Iwamoto, Y., German, M. S., Bell, G. I. Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese. Diabetes 47: 1356-1358, 1998. 3. Hartigan, D. J., Rubenstein, J. L. The cDNA sequence of murine Nkx-2.2. Gene 168: 271-272, 1996.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

4821

Applications Notes

6

Gene Name Synonym

NK2 homeobox 2

Protein Name

Homeobox protein Nkx-2.2

Isotype

IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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