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Anti-MTHFD2 Antibody Picoband®

Boster Bio Anti-MTHFD2 Antibody Picoband® catalog # A06465-2. Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Specifications

Background

This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7.

Synonyms

MTHFD2; NMDMC; Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase; EC 1.5.1.15; Methenyltetrahydrofolate cyclohydrolase; EC 3.5.4.9]

Gene Name

MTHFD2

Gene ID

10797

UniProt

P13995

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human MTHFD2 recombinant protein (Position: R13-N350) . Human MTHFD2 shares 92.9% amino acid (aa) sequence identity with mouse MTHFD2.

Clonality

Polyclonal

Applications

WB, Flow Cytometry, ELISA

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Lyophilized

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

References & Citations

1. Ben-Sahra, I., Hoxhaj, G., Ricoult, S. J. H., Asara, J. M., Manning, B. D. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science 351: 728-733, 2016. 2. Di Pietro, E., Sirois, J., Tremblay, M. L., MacKenzie, R. E. Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development. Molec. Cell. Biol. 22: 4158-4166, 2002. 3. Gross, M. B. Personal Communication. Baltimore, Md. 8/29/2022.

Storage Conditions

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Calculated Molecular Weight

38 kDa

Observed Molecular Weight

35 kDa

Applications Notes

6

Gene Name Synonym

Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase

Protein Name

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

Isotype

Rabbit IgG

Contents

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

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