Anti-MTHFD2 Antibody Picoband® Biotin Conjugated
Product Specifications
Background
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7.
Synonyms
MTHFD2; NMDMC; Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase; EC 1.5.1.15; Methenyltetrahydrofolate cyclohydrolase; EC 3.5.4.9]
Gene Name
MTHFD2
Gene ID
10797
UniProt
P13995
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human MTHFD2 recombinant protein (Position: R13-N350) . Human MTHFD2 shares 92.9% amino acid (aa) sequence identity with mouse MTHFD2.
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Ben-Sahra, I., Hoxhaj, G., Ricoult, S. J. H., Asara, J. M., Manning, B. D. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science 351: 728-733, 2016. 2. Di Pietro, E., Sirois, J., Tremblay, M. L., MacKenzie, R. E. Mitochondrial NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase is essential for embryonic development. Molec. Cell. Biol. 22: 4158-4166, 2002. 3. Gross, M. B. Personal Communication. Baltimore, Md. 8/29/2022.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.
Calculated Molecular Weight
38 kDa
Gene Name Synonym
Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Protein Name
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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