Anti-ATP6V1H Antibody Picoband® HRP Conjugated

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

ATP6V1H; CGI-11; V-type proton ATPase subunit H; V-ATPase subunit H; Nef-binding protein 1; NBP1; Protein VMA13 homolog; V-ATPase 50/57 kDa subunits; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFD

E.coli-derived human ATP6V1H recombinant protein (Position: Q40-S483) . Human ATP6V1Hshares 98.4% and 98% amino acid (aa) sequence identity with mouse and rat ATP6V1H, respectively.

1. Geyer, M., Fackler, O. T., Peterlin, B. M. Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptins. Molec. Biol. Cell 13: 2045-2056, 2002. 2. Geyer, M., Yu, H., Mandic, R., Linnemann, T., Zheng, Y.-H., Fackler, O. T., Peterlin, B. M. Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery. J. Biol. Chem. 277: 28521-28529, 2002. 3. Lu, X., Yu, H., Liu, S.-H., Brodsky, F. M., Peterlin, B. M. Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4. Immunity 8: 647-656, 1998.