Anti-Glypican 1/GPC1 Antibody Picoband®

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

E.coli-derived human Glypican 1/GPC1 recombinant protein (Position: E72-N472) . Human Glypican 1/GPC1shares 89.8% and 90% amino acid (aa) sequence identity with mouse and rat Glypican 1/GPC1, respectively.

1. Aikawa, T., Whipple, C. A., Lopez, M. E., Gunn, J., Young, A., Lander, A. D., Korc, M. Glypican-1 modulates the angiogenic and metastatic potential of human and mouse cancer cells. J. Clin. Invest. 118: 89-99, 2008. 2. Karumanchi, S. A., Jha, V., Ramchandran, R., Karihaloo, A., Tsiokas, L., Chan, B., Dhanabal, M., Hanai, J., Venkataraman, G., Shriver, Z., Keiser, N., Kalluri, R., and 9 others. Cell surface glypicans are low-affinity endostatin receptors. Molec. Cell 7: 811-822, 2001. 3. Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., Reissfelder, C., Pilarsky, C., Fraga, M. F., Piwnica-Worms, D., Kalluri, R. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature 523: 177-182, 2015. Note: Erratum: Nature 610: E15-E17, 2022.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.