Anti-NKX6-1 Antibody Picoband® HRP Conjugated

In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].

1. Gross, M. B. Personal Communication. Baltimore, Md. 8/31/2016. 2. Inoue, H., Rudnick, A., German, M. S., Veile, R., Donis-Keller, H., Permutt, M. A. Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene. Genomics 40: 367-370, 1997. 3. Iype, T., Taylor, D. G., Ziesmann, S. M., Garmey, J. C., Watada, H., Mirmira, R. G. The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1. Molec. Endocr. 18: 1363-1375, 2004.