Anti-NKX6-1 Antibody Picoband® Biotin Conjugated
Product Specifications
Background
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].
Synonyms
NKX6-1; NKX6A; Homeobox protein Nkx-6.1; Homeobox protein NK-6 homolog A
Gene Name
NKX6-1
Gene ID
4825
UniProt
P78426
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human NKX6-1.
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Gross, M. B. Personal Communication. Baltimore, Md. 8/31/2016. 2. Inoue, H., Rudnick, A., German, M. S., Veile, R., Donis-Keller, H., Permutt, M. A. Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene. Genomics 40: 367-370, 1997. 3. Iype, T., Taylor, D. G., Ziesmann, S. M., Garmey, J. C., Watada, H., Mirmira, R. G. The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1. Molec. Endocr. 18: 1363-1375, 2004.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.
Calculated Molecular Weight
38 kDa
Gene Name Synonym
NK6 homeobox 1
Protein Name
Homeobox protein Nkx-6.1
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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