Anti-NLGN1 Antibody Picoband®

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.

A synthetic peptide corresponding to a sequence in the middle region of human NLGN1. Human NLGN1 shares 100% amino acid (aa) sequence identity with both mouse and rat NLGN1.

1. Arac, D., Boucard A. A., Ozkan, E., Strop, P., Newell, E., Sudhof, T. C., Brunger, A. T. Structures of neuroligin-1 and the neuroligin-1/neurexin-1-beta complex reveal specific protein-protein and protein-Ca (2+) interactions. Neuron 56: 992-1003, 2007. 2. Boucard, A. A., Chubykin, A. A., Comoletti, D., Taylor, P., Sudhof, T. C. A splice code for trans-synaptic cell adhesion mediated by binding of neuroligin 1 to alpha- and beta-neurexins. Neuron 48: 229-236, 2005. 3. Chih, B., Engelman, H., Scheiffele, P. Control of excitatory and inhibitory synapse formation by neuroligins. Science 307: 1324-1328, 2005. Note: Erratum: Science 308: 1413 only, 2005.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.