Anti-Hepsin/HPN Antibody Picoband® Fluoro647 Conjugated

This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants.

HPN; TMPRSS1; Serine protease hepsin; EC 3.4.21.106; Transmembrane protease serine 1 [Cleaved into: Serine protease hepsin non-catalytic chain; Serine protease hepsin catalytic chain]

E.coli-derived human Hepsin/HPN recombinant protein (Position: D47-L417) . Human Hepsin/HPNshares 90% and 89.2% amino acid (aa) sequence identity with mouse and rat Hepsin/HPN, respectively.

1. Dhanasekaran, S. M., Barrette, T. R., Ghosh, D., Shah, R., Varambally, S., Kurachi, K., Pienta, K. J., Rubin, M. A., Chinnaiyan, A. M. Delineation of prognostic biomarkers in prostate cancer. Nature 412: 822-826, 2001. 2. Guipponi, M., Toh, M.-Y., Tan, J., Park, D., Hanson, K., Ballana, E., Kwong, D., Cannon, P. Z. F., Wu, Q., Gout, A., Delorenzi, M., Speed, T. P., Smith, R. J. H., Dahl, H. H., Petersen, M., Teasdale, R. D., Estivill, X., Park, W. J., Scott, H. S. An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss. Hum. Mutat. 29: 130-141, 2008. 3. Leytus, S. P., Loeb, K. R., Hagen, F. S., Kurachi, K., Davie, E. W. A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells. Biochemistry 27: 1067-1074, 1988.