Anti-MOCA/DOCK3 Antibody Picoband®

This gene is specifically expressed in the central nervous system (CNS) . It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs) . This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP) . The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement.

E.coli-derived human MOCA/DOCK3 recombinant protein (Position: E88-K2006) . Human MOCA/DOCK3 shares 98% amino acid (aa) sequence identity with mouse MOCA/DOCK3.

1. Chen, Q., Peto, C. A., Shelton, G. D., Mizisin, A., Sawchenko, P. E., Schubert, D. Loss of modifier of cell adhesion reveals a pathway leading to axonal degeneration. J. Neurosci. 29: 118-130, 2009. 2. de Silva, M. G., Elliott, K., Dahl, H.-H., Fitzpatrick, E., Wilcox, S., Delatycki, M., Williamson, R., Efron, D., Lynch, M., Forrest, S. Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype. J. Med. Genet. 40: 733-740, 2003. 3. Helbig, K. L., Mroske, C., Moorthy, D., Sajan, S. A., Velinov, M. Biallelic loss-of-function variants in DOCK3 cause muscle hypotonia, ataxia, and intellectual disability. Clin. Genet. 92: 430-433, 2017. Note: Erratum: Clin. Genet. 93: 1117 only, 2018.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.