Anti-EIF4H Antibody Picoband® HRP Conjugated

This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.

E.coli-derived human EIF4H recombinant protein (Position: M1-E248) . Human EIF4Hshares 98.8% and 98% amino acid (aa) sequence identity with mouse and rat EIF4H, respectively.

1. Osborne, L. R., Martindale, D., Scherer, S. W., Shi, X.-M., Huizenga, J., Heng, H. H. Q., Costa, T., Pober, B., Lew, L., Brinkman, J., Rommens, J., Koop, B., Tsui, L.-C. Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients. Genomics 36: 328-336, 1996. 2. Richter-Cook, N. J., Dever, T. E., Hensold, J. O., Merrick, W. C. Purification and characterization of a new eukaryotic protein translation factor: eukaryotic initiation factor 4H. J. Biol. Chem. 273: 7579-7587, 1998.