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Anti-EREG Antibody Picoband® HRP Conjugated

Product Specifications

Background

This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4) . The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues.

Synonyms

EREG; Proepiregulin [Cleaved into: Epiregulin; EPR]

Gene Name

EREG

Gene ID

2069

UniProt

O14944

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human EREG recombinant protein (Position: F24-V169) . Human EREGshares 84.1% and 83.4% amino acid (aa) sequence identity with mouse and rat EREG, respectively.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Gupta, G. P., Nguyen, D. X., Chiang, A. C., Bos, P. D., Kim, J. Y., Nadal, C., Gomis, R. R., Manova-Todorova, K., Massague, J. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 446: 765-770, 2007. 2. Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., Massague, J. Genes that mediate breast cancer metastasis to lung. Nature 436: 518-524, 2005. 3. Park, J.-Y., Su, Y.-Q., Ariga, M., Law, E., Jin, S.-L. C., Conti, M. EGF-like growth factors as mediators of LH action in the ovulatory follicle. Science 303: 682-684, 2004.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

19 kDa

Gene Name Synonym

Epiregulin

Protein Name

Proepiregulin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4.

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