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Anti-EREG Antibody Picoband® FITC Conjugated

Product Specifications

Background

This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4) . The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues.

Synonyms

EREG; Proepiregulin [Cleaved into: Epiregulin; EPR]

Gene Name

EREG

Gene ID

2069

UniProt

O14944

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human EREG recombinant protein (Position: F24-V169) . Human EREGshares 84.1% and 83.4% amino acid (aa) sequence identity with mouse and rat EREG, respectively.

Clonality

Polyclonal

Applications

Flow Cytometry

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Gupta, G. P., Nguyen, D. X., Chiang, A. C., Bos, P. D., Kim, J. Y., Nadal, C., Gomis, R. R., Manova-Todorova, K., Massague, J. Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 446: 765-770, 2007. 2. Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., Massague, J. Genes that mediate breast cancer metastasis to lung. Nature 436: 518-524, 2005. 3. Park, J.-Y., Su, Y.-Q., Ariga, M., Law, E., Jin, S.-L. C., Conti, M. EGF-like growth factors as mediators of LH action in the ovulatory follicle. Science 303: 682-684, 2004.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

19 kDa

Applications Notes

6

Gene Name Synonym

Epiregulin

Protein Name

Proepiregulin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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