Anti-MIB2 Antibody Picoband® HRP Conjugated

The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion.

MIB2; SKD; ZZANK1; E3 ubiquitin-protein ligase MIB2; EC 2.3.2.27; Mind bomb homolog 2; Novel zinc finger protein; Novelzin; Putative NF-kappa-B-activating protein 002N; RING-type E3 ubiquitin transferase MIB2; Skeletrophin; Zinc finger ZZ type with ankyrin repeat domain protein 1

E.coli-derived human MIB2 recombinant protein (Position: A71-I572) . Human MIB2shares 90.3% and 89.7% amino acid (aa) sequence identity with mouse and rat MIB2, respectively.

1. Feltham, R., Jamal, K., Tenev, T., Liccardi, G., Jaco, I., Domingues, C. M., Morris, O., John, S. W., Annibaldi, A., Widya, M., Kearney, C. J., Clancy, D., and 10 others. Mind bomb regulates cell death during TNF signaling by suppressing RIPK1's cytotoxic potential. Cell Rep. 23: 470-484, 2018. 2. Koo, B.-K., Yoon, K.-J., Yoo, K.-W., Lim, H.-S., Song, R., So, J.-H., Kim, C.-H., Kong, Y.-Y. Mind bomb-2 is an E3 ligase for Notch ligand. J. Biol. Chem. 280: 22335-22342, 2005. 3. Piccolo, P., Attanasio, S., Secco, I., Sangermano, R., Strisciuglio, C., Limongelli, G., Miele, E., Mutarelli, M., Banfi, S., Nigro, V., Pons, T., Valencia, A., and 12 others. MIB2 variants altering NOTCH signalling result in left ventricle hypertrabeculation /non-compaction and are associated with Menetrier-like gastropathy. Hum. Molec. Genet. 26: 33-43, 2017.