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Anti-APTX Antibody Picoband® HRP Conjugated

Product Specifications

Background

This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene.

Synonyms

APTX; AXA1; Aprataxin; EC 3.1.11.7; EC 3.1.12.2; Forkhead-associated domain histidine triad-like protein; FHA-HIT

Gene Name

APTX

Gene ID

54840

UniProt

Q7Z2E3

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human APTX recombinant protein (Position: E46-Q356) . Human APTXshares 84.8% and 80.9% amino acid (aa) sequence identity with mouse and rat APTX, respectively.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Ahel, I., Rass, U., El-Khamisy, S. F., Katyal, S., Clements, P. M., McKinnon, P. J., Caldecott, K. W., West, S. C. The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature 443: 713-716, 2006. 2. Amouri, R., Moreira, M.-C., Zouari, M., El Euch, G., Barhoumi, C., Kefi, M., Belal, S., Koenig, M., Hentati, F. Aprataxin gene mutations in Tunisian families Neurology 63: 928-929, 2004. 3. Castellotti, B., Mariotti, C., Rimoldi, M., Fancellu, R., Plumari, M., Caimi, S., Uziel, G., Nardocci, N., Moroni, I., Zorzi, G., Pareyson, D., Di Bella, D., Di Donato, S., Taroni, F., Gellera, C. Ataxia with oculomotor apraxia type 1 (AOA1) : novel and recurrent aprataxin mutations, coenzyme Q10 analyses, and clinical findings in Italian patients. Neurogenetics 12: 193-201, 2011.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

41 kDa

Gene Name Synonym

Aprataxin

Protein Name

Aprataxin

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4.

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