Anti-MCAT Antibody Picoband®

The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms.

MCAT; MT; Malonyl-CoA-acyl carrier protein transacylase, mitochondrial; MCT; EC 2.3.1.39; Mitochondrial malonyl CoA:ACP acyltransferase; Mitochondrial malonyltransferase; [Acyl-carrier-protein] malonyltransferase

1. Gerber, S., Orssaud, C., Kaplan, J., Johansson, C., Rozet, J. M. MCAT mutations cause nuclear LHON-like optic neuropathy. Genes 12: 521, 2021. 2. Li, H., Yuan, S., Minegishi, Y., Suga, A., Yoshitake, K., Sheng, X., Ye, J., Smith, S., Bunkoczi, G., Yamamoto, M., Iwata, T. Novel mutations in malonyl-CoA-acyl carrier protein transacylase provoke autosomal recessive optic neuropathy. Hum. Molec. Genet. 29: 444-458, 2020. 3. Webb, B. D., Nowinski, S. M., Solmonson, A., Ganesh, J., Rodenburg, R. J., Leandro, J., Evans, A., Vu, H. S., Naidich, T. P., Gelb, B. D., DeBerardinis, R. J., Rutter, J., Houten, S. M. Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency. eLife 12: e68047, 2023.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.