Anti-NEUROD1 Antibody Picoband®

This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus.

A synthetic peptide corresponding to a sequence at the N-terminus of human NEUROD1. Human NEUROD1 shares 90.9% amino acid (aa) sequence identity with both mouse and rat NEUROD1.

1. Fajans, S. S., Bell, G. I., Polonsky, K. S. Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. New Eng. J. Med. 345: 971-980, 2001. 2. Lee, J. E., Hollenberg, S. M., Snider, L., Turner, D. L., Lipnick, N., Weintraub, H. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. Science 268: 836-844, 1995. 3. Liu, M., Pereira, F. A., Price, S. D., Chu, M., Shope, C., Himes, D., Eatock, R. A., Brownell, W. E., Lysakowski, A., Tsai, M.-J. Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems. Genes Dev. 14: 2839-2854, 2000.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.