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Anti-PYGM Antibody Picoband® Biotin Conjugated

Product Specifications

Background

This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants.

Synonyms

PYGM; Glycogen phosphorylase, muscle form; EC 2.4.1.1; Myophosphorylase

Gene Name

PYGM

Gene ID

5837

UniProt

P11217

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human PYGM recombinant protein (Position: V390-R804) . Human PYGMshares 95.9% and 94.2% amino acid (aa) sequence identity with mouse and rat PYGM, respectively.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Andreu, A. L., Nogales-Gadea, G., Cassandrini, D., Arenas, J., Bruno, C. McArdle disease: molecular genetic update. Acta Myol. 26: 53-57, 2007. 2. Bartram, C., Edwards, R. H. T., Clague, J., Beynon, R. J. McArdle's disease: a nonsense mutation in exon 1 of the muscle glycogen phosphorylase gene explains some but not all cases. Hum. Molec. Genet. 2: 1291-1293, 1993. 3. Bruno, C., Lofberg, M., Tamburino, L., Jankala, H., Hadjigeorgiou, G. M., Andreu, A. L., Shanske, S., Somer, H., DiMauro, S. Molecular characterization of McArdle's disease in two large Finnish families. J. Neurol. Sci. 165: 121-125, 1999.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

97 kDa

Gene Name Synonym

Glycogen phosphorylase, muscle associated

Protein Name

Glycogen phosphorylase, muscle form

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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