Anti-PYGM Antibody Picoband®

This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants.

E.coli-derived human PYGM recombinant protein (Position: V390-R804) . Human PYGMshares 95.9% and 94.2% amino acid (aa) sequence identity with mouse and rat PYGM, respectively.

1. Andreu, A. L., Nogales-Gadea, G., Cassandrini, D., Arenas, J., Bruno, C. McArdle disease: molecular genetic update. Acta Myol. 26: 53-57, 2007. 2. Bartram, C., Edwards, R. H. T., Clague, J., Beynon, R. J. McArdle's disease: a nonsense mutation in exon 1 of the muscle glycogen phosphorylase gene explains some but not all cases. Hum. Molec. Genet. 2: 1291-1293, 1993. 3. Bruno, C., Lofberg, M., Tamburino, L., Jankala, H., Hadjigeorgiou, G. M., Andreu, A. L., Shanske, S., Somer, H., DiMauro, S. Molecular characterization of McArdle's disease in two large Finnish families. J. Neurol. Sci. 165: 121-125, 1999.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.