Anti-ALADIN/AAAS Antibody Picoband®

The protein encoded by this gene is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this gene are a cause of achalasia-addisonianism-alacrima syndrome (AAAS), also called triple-A syndrome or Allgrove syndrome. Two transcript variants encoding different isoforms have been found for this gene.

E.coli-derived human ALADIN/AAAS recombinant protein (Position: R13-K466) . Human ALADIN/AAAS shares 94.3% amino acid (aa) sequence identity with mouse ALADIN/AAAS.

1.Bitetto, G., Ronchi, D., Bonato, S., Pittaro, A., Compagnoni, G. M., Bordoni, A., Salani, S., Frattini, E., Lopez, G., Cribiu, F. M., Corti, S., Comi, G. P., Bresolin, N., Di Fonzo, A. Loss of the nucleoporin aladin in central nervous system and fibroblasts of Allgrove syndrome. Hum. Molec. Genet. 28: 3921-3927, 2019. 2. Chang, A. J., Kline, M. M., Currie, Y., Perez, M. O., Hartiala, J., Wijesuriya, H., Buchanan, T. A., Watanabe, R. M., Allayee, H. Allgrove syndrome in a Mexican American family is caused by an ancestral mutation derived from North Africa. (Letter) Clin. Genet. 73: 385-387, 2008. 3. Cronshaw, J. M., Matunis, M. J. The nuclear pore complex protein ALADIN is mislocalized in triple A syndrome. Proc. Nat. Acad. Sci. 100: 5823-5827, 2003.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.