Anti-HIF1AN Antibody Picoband® APC Conjugated
Product Specifications
Background
Enables several functions, including 2-oxoglutarate-dependent dioxygenase activity; NF-kappaB binding activity; and transition metal ion binding activity. Involved in negative regulation of Notch signaling pathway and positive regulation of myoblast differentiation. Located in cytosol; nucleoplasm; and perinuclear region of cytoplasm.
Synonyms
HIF1AN; FIH1; Hypoxia-inducible factor 1-alpha inhibitor; EC 1.14.11.30; EC 1.14.11.n4; Factor inhibiting HIF-1; FIH-1; Hypoxia-inducible factor asparagine hydroxylase
Gene Name
HIF1AN
Gene ID
55662
UniProt
Q9NWT6
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human HIF1AN recombinant protein (Position: D28-N349) . Human HIF1AN shares 98.4% amino acid (aa) sequence identity with mouse HIF1AN.
Clonality
Polyclonal
Applications
Flow Cytometry
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Hoff, S., Halbritter, J., Epting, D., Frank, V., Nguyen, T.-M. T., van Reeuwijk, J., Boehlke, C., Schell, C., Yasunaga, T., Helmstadter, M., Mergen, M., Filhol, E., and 29 others. ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3. Nature Genet. 45: 951-956, 2013. 2. Mahon, P. C., Hirota, K., Semenza, G. L. FIH-1: a novel protein that interacts with HIF-1-alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15: 2675-2686, 2001.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
40 kDa
Applications Notes
6
Gene Name Synonym
Hypoxia inducible factor 1 subunit alpha inhibitor
Protein Name
Hypoxia-inducible factor 1-alpha inhibitor
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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