Anti-Hephaestin/HEPH Antibody Picoband® APC Conjugated

Enables ferroxidase activity. Involved in intestinal iron absorption; multicellular organismal-level iron ion homeostasis; and positive regulation of iron export across plasma membrane. Acts upstream of or within erythrocyte differentiation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in basolateral plasma membrane. Orthologous to human HEPH (hephaestin) .

E.coli-derived human Hephaestin/HEPH recombinant protein (Position: E348-Q1157) . Mouse Hephaestin/HEPHshares 85.6% and 96.2% amino acid (aa) sequence identity with human and rat Hephaestin/HEPH, respectively.

1. Anderson, G. J., Murphy, T. L., Cowley, L., Evans, B. A., Halliday, J. W., McLaren, G. D. Mapping the gene for sex-linked anemia: an inherited defect of intestinal iron absorption in the mouse. Genomics 48: 34-39, 1998. 2. Bannerman, R. M. Genetic defects of iron transport. Fed. Proc. 35: 2281-2285, 1976. 3. Edwards, J. A., Hoke, J. E., Mattioli, M., Reichlin, M. Ferritin distribution and synthesis in sex-linked anemia. J. Lab. Clin. Med. 90: 68-76, 1977.