Anti-HAL Antibody Picoband® Biotin Conjugated
Product Specifications
Background
Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms
HAL; HIS; Histidine ammonia-lyase; Histidase; EC 4.3.1.3
Gene Name
HAL
Gene ID
3034
UniProt
P42357
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human HAL recombinant protein (Position: D65-R632) . Human HALshares 95.2% and 95.4% amino acid (aa) sequence identity with mouse and rat HAL, respectively.
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Kacser, H. K., Bulfield, G., Wallace, M. E. Histidinaemia mutant in the mouse. Nature 244: 77-79, 1973. 2. Kanarek, N., Keys, H. R., Cantor, J. R., Lewis, C. A., Chan, S. H., Kunchok, T., Abu-Remaileh, M., Freinkman, E., Schweitzer, L. D., Sabatini, D. M. Histidine catabolism is a major determinant of methotrexate sensitivity. Nature 559: 632-636, 2018. Note: Erratum: Nature 602: E17-E18, 2022. 3. Kawai, Y., Moriyama, A., Asai, K., Coleman-Campbell, C. M., Sumi, S., Morishita, H., Suchi, M. Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene. Hum. Genet. 116: 340-346, 2005. Note: Erratum: Hum. Genet. 118: 531-532, 2005.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.
Calculated Molecular Weight
73 kDa
Gene Name Synonym
Histidine ammonia-lyase
Protein Name
Histidine ammonia-lyase
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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