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Anti-HAL Antibody Picoband® Biotin Conjugated

Product Specifications

Background

Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene.

Synonyms

HAL; HIS; Histidine ammonia-lyase; Histidase; EC 4.3.1.3

Gene Name

HAL

Gene ID

3034

UniProt

P42357

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human HAL recombinant protein (Position: D65-R632) . Human HALshares 95.2% and 95.4% amino acid (aa) sequence identity with mouse and rat HAL, respectively.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Kacser, H. K., Bulfield, G., Wallace, M. E. Histidinaemia mutant in the mouse. Nature 244: 77-79, 1973. 2. Kanarek, N., Keys, H. R., Cantor, J. R., Lewis, C. A., Chan, S. H., Kunchok, T., Abu-Remaileh, M., Freinkman, E., Schweitzer, L. D., Sabatini, D. M. Histidine catabolism is a major determinant of methotrexate sensitivity. Nature 559: 632-636, 2018. Note: Erratum: Nature 602: E17-E18, 2022. 3. Kawai, Y., Moriyama, A., Asai, K., Coleman-Campbell, C. M., Sumi, S., Morishita, H., Suchi, M. Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene. Hum. Genet. 116: 340-346, 2005. Note: Erratum: Hum. Genet. 118: 531-532, 2005.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

73 kDa

Gene Name Synonym

Histidine ammonia-lyase

Protein Name

Histidine ammonia-lyase

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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