Anti-GTF2B Antibody Picoband® APC Conjugated

This gene encodes the general transcription factor IIB, one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II.

E.coli-derived human GTF2B recombinant protein (Position: N17-D298) . Human GTF2B shares 100% amino acid (aa) sequence identity with both mouse and rat GTF2B.

1. Abendroth, F. D., Peterson, S. R., Galman, M., Suwa, A., Hardin, J. A., Dynan, W. S. Identification of human autoantibodies to transcription factor IIB. Nucleic Acids Res. 23: 2770-2774, 1995. 2. Bagby, S., Kim, S., Maldonado, E., Tong, K. I., Reinberg, D., Ikura, M. Solution structure of the C-terminal core domain of human TFIIB: similarity to cyclin A and interaction with TATA-binding protein. Cell 82: 857-867, 1995. 3. Bushnell, D. A., Westover, K. D., Davis, R. E., Kornberg, R. D. Structural basis of transcription: an RNA polymerase II-TFIIB cocrystal at 4.5 angstroms. Science 303: 983-988, 2004.