Anti-GSS Antibody Picoband® APC Conjugated

Glutathione is important for a variety of biological functions, including protection of cells from oxidative damage by free radicals, detoxification of xenobiotics, and membrane transport. The protein encoded by this gene functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in this gene are a cause of glutathione synthetase deficiency.

E.coli-derived human GSS recombinant protein (Position: M1-H456) . Human GSSshares 88.2% and 87.7% amino acid (aa) sequence identity with mouse and rat GSS, respectively.

1. Dahl, N., Pigg, M., Ristoff, E., Gali, R., Carlsson, B., Mannervik, B., Larsson, A., Board, P. Missense mutations in the human glutathione synthetase gene result in severe metabolic acidosis, 5-oxoprolinuria, hemolytic anemia and neurological dysfunction. Hum. Molec. Genet. 6: 1147-1152, 1997. 2. Meister, A., Anderson, M. E. Glutathione. Annu. Rev. Biochem. 52: 711-760, 1983. 3. Mohler, D. N., Majerus, P. W., Minnich, V., Hess, C. E., Garrick, M. D. Glutathione synthetase deficiency as a cause of hereditary hemolytic disease. New Eng. J. Med. 283: 1253-1257, 1970.