Anti-MBD3 Antibody Picoband®

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD) . The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene.

A synthetic peptide corresponding to a sequence at the C-terminus of human MBD3. Human MBD3 shares 100% amino acid (aa) sequence identity with mouse MBD3.

1. Aguilera, C., Nakagawa, K., Sancho, R., Chakraborty, A., Hendrich, B., Behrens, A. c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex. Nature 469: 231-235, 2011. 2. Fujitomo, T., Daigo, Y., Matsuda, K., Ueda, K., Nakamura, Y. Identification of a nuclear protein, LRRC42, involved in lung carcinogenesis. Int. J. Oncol. 45: 147-156, 2014. 3. Hendrich, B., Abbott, C., McQueen, H., Chambers, D., Cross, S., Bird, A. Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes. Mammalian Genome 10: 906-912, 1999.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.