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Anti-PDCD2 Antibody Picoband® HRP Conjugated

Product Specifications

Background

This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12.

Synonyms

PDCD2; RP8; ZMYND7; Programmed cell death protein 2; Zinc finger MYND domain-containing protein 7; Zinc finger protein Rp-8

Gene Name

PDCD2

Gene ID

5134

UniProt

Q16342

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human PDCD2 recombinant protein (Position: R7-Q254) . Human PDCD2 shares 82.2% and 81.7% amino acid (aa) sequence identity with mouse and rat PDCD2, respectively.

Clonality

Polyclonal

Applications

WB, IHC, ELISA

Purification

Immunogen affinity purified.

Form

Liquid

References & Citations

1. Baron, B. W., Anastasi, J., Thirman, M. J., Furukawa, Y., Fears, S., Kim, D. C., Simone, F., Birkenbach, M., Montag, A., Sadhu, A., Zeleznik-Le, N., McKeithan, T. W. The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis. Proc. Nat. Acad. Sci. 99: 2860-2865, 2002. 2. Baron, B. W., Zeleznik-Le, N., Baron, M. J., Theisler, C., Huo, D., Krasowski, M. D., Thirman, M. J., Baron, R. M., Baron, J. M. Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas. Proc. Nat. Acad. Sci. 104: 7449-7454, 2007. 3. Cohen, J. J., Duke, R. C. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immun. 132: 38-42, 1984.

Storage Conditions

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

Calculated Molecular Weight

39 kDa

Gene Name Synonym

Programmed cell death 2

Protein Name

Programmed cell death protein 2

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4.

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