Anti-PDCD2 Antibody Picoband® Biotin Conjugated
Product Specifications
Background
This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12.
Synonyms
PDCD2; RP8; ZMYND7; Programmed cell death protein 2; Zinc finger MYND domain-containing protein 7; Zinc finger protein Rp-8
Gene Name
PDCD2
Gene ID
5134
UniProt
Q16342
Host
Rabbit
Reactivity
Human, Mouse, Rat
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human PDCD2 recombinant protein (Position: R7-Q254) . Human PDCD2 shares 82.2% and 81.7% amino acid (aa) sequence identity with mouse and rat PDCD2, respectively.
Clonality
Polyclonal
Applications
WB, IHC, ELISA
Purification
Immunogen affinity purified.
Form
Liquid
References & Citations
1. Baron, B. W., Anastasi, J., Thirman, M. J., Furukawa, Y., Fears, S., Kim, D. C., Simone, F., Birkenbach, M., Montag, A., Sadhu, A., Zeleznik-Le, N., McKeithan, T. W. The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis. Proc. Nat. Acad. Sci. 99: 2860-2865, 2002. 2. Baron, B. W., Zeleznik-Le, N., Baron, M. J., Theisler, C., Huo, D., Krasowski, M. D., Thirman, M. J., Baron, R. M., Baron, J. M. Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas. Proc. Nat. Acad. Sci. 104: 7449-7454, 2007. 3. Cohen, J. J., Duke, R. C. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immun. 132: 38-42, 1984.
Storage Conditions
At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.
Calculated Molecular Weight
39 kDa
Gene Name Synonym
Programmed cell death 2
Protein Name
Programmed cell death protein 2
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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