Anti-PDCD2 Antibody Picoband®

This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12.

E.coli-derived human PDCD2 recombinant protein (Position: R7-Q254) . Human PDCD2 shares 82.2% and 81.7% amino acid (aa) sequence identity with mouse and rat PDCD2, respectively.

1. Baron, B. W., Anastasi, J., Thirman, M. J., Furukawa, Y., Fears, S., Kim, D. C., Simone, F., Birkenbach, M., Montag, A., Sadhu, A., Zeleznik-Le, N., McKeithan, T. W. The human programmed cell death-2 (PDCD2) gene is a target of BCL6 repression: implications for a role of BCL6 in the down-regulation of apoptosis. Proc. Nat. Acad. Sci. 99: 2860-2865, 2002. 2. Baron, B. W., Zeleznik-Le, N., Baron, M. J., Theisler, C., Huo, D., Krasowski, M. D., Thirman, M. J., Baron, R. M., Baron, J. M. Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas. Proc. Nat. Acad. Sci. 104: 7449-7454, 2007. 3. Cohen, J. J., Duke, R. C. Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immun. 132: 38-42, 1984.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.