Anti-USP14 Antibody Picoband® Biotin Conjugated

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

USP14; TGT; Ubiquitin carboxyl-terminal hydrolase 14; EC 3.4.19.12; Deubiquitinating enzyme 14; Ubiquitin thioesterase 14; Ubiquitin-specific-processing protease 14

1. Dennehey, B. K., Gutches, D. G., McConkey, E. H., Krauter, K. S. Inversion, duplication, and changes in gene context are associated with human chromosome 18 evolution. Genomics 83: 493-501, 2004. 2. Deshpande, K. L., Seubert, P. H., Tillman, D. M., Farkas, W. R., Katze, J. R. Cloning and characterization of cDNA encoding the rabbit tRNA-guanine transglycosylase 60-kilodalton subunit. Arch. Biochem. Biophys. 326: 1-7, 1996. 3. Gross, M. B. Personal Communication. Baltimore, Md. 7/13/2015.